Source
PubMed
Abstract
Background: People with sickle cell disease (SCD) are at risk for accelerated biological aging and functional decline due to both age and SCD-related stressors. Frailty is characterized by decreased physiologic reserve and increased vulnerability to stressors that can lead to disability and death. The purpose of this study was to evaluate frailty phenotype in adults with SCD and identify factors associated with frailty.
Methods: Frailty was defined by meeting ≥3 of the following criteria: slowness, weakness, weight loss, low physical activity, and exhaustion. Participants meeting 1-2 criteria were prefrail and "robust" if no criteria were present.
News Url