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Sickle cell disease (SCD) remains a formidable hematological public health challenge, particularly among tribal populations in central and southern India. Launch of the National Sickle Cell Anaemia Elimination Mission (NSCAEM), which aims to eliminate SCD as a public health problem by 2047, places the Indian hematology community at an inflection point [1]. The focus must now extend beyond managing acute crises to instituting holistic systems for early detection, comorbidity management, and curative strategies. This issue of the Indian Journal of Hematology and Blood Transfusion presents timely studies and guidelines in this regard [2,3,4,5,6,7,8,9,10,11].
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