Sickle Cell Disease is included as an EHA 2026 disease-area keyword under non-malignant hematology, with relevant subtypes including Sickle Cell Pain Crises, Vaso-Occlusive Crises. This row helps turn conference abstracts into disease-focused SEO article clusters and makes it easier to connect drugs, targets, and trials to marketable content angles.
Executive Summary
Sickle cell disease (SCD) is the most prevalent inherited hemoglobinopathy worldwide. The single point mutation in HBB (Glu6Val) produces hemoglobin S, which polymerizes under deoxygenated conditions and rigidifies erythrocytes. People living with SCD experience recurrent vaso-occlusive crises, chronic hemolytic anemia, and organ damage. The disease burden falls disproportionately on populations of African ancestry and on under-resourced health systems globally.