In the manuscript “Sickle Cell Disease: From Ancient Origins to Modern Break-2 throughs in Gene Therapy” by Drs. Bawo Ikolo et al, the authors examine various aspects of sickle cell anemia (SCA), ranging from the disease's historical origins to its molecular characteristics and clinical manifestations. They also review inheritance patterns, screening strategies, and the spectrum of current and emerging treatment modalities.
The manuscript provides comprehensive information, and the data are presented clearly. I have no substantive objections; I would merely like to clarify a few details.
- Patients with sickle cell anemia (SCA) exhibit a disproportionately high rate of comorbid psychiatric disorders compared to healthy individuals. However, the causal relationship between SCA and mental health conditions is complex and not yet fully understood; a complex bidirectional association is believed to exist. There are existing publications on this topic, and I believe it would be appropriate to give them due attention.