Clinical Trials and Research

AbstractBackgroundVitamin A is involved in the proliferation and maintenance of the epithelial cells of the respiratory tract. Since maintenance of the integrity of…

APhase III trial of Novo Nordisk’s once-daily tablet has met both co-primary endpoints, reducing vaso-occlusive crises (VOC) and increasing haemoglobin (Hb)…

Sickle cell disease (SCD) is characterized by abnormal polymerization of deoxygenated hemoglobin S. This polymerization leads to the distinctive sickling of red…

ABSTRACT:Sickle cell anemia is a severe inherited blood disorder caused by a mutation in the beta globin gene, leading to the formation of abnormal hemoglobin S and…

Sickle cell patients are more likely than other patients to have negative descriptions in their medical charts, such as “noncompliant” and “noncooperative,”…

AbstractBackgroundSickle cell disease (SCD) is one of the most common monogenic disorders in the world. Patients with SCD have chronic hemolytic anemia and…

Department of Development Studies, School of Public Health and Social Sciences, Muhimbili University of Health and Allied Sciences, Dar es Salaam P.O. Box 65001,…

AbstractSickle Cell Anaemia is a genetic disease-causing high morbidity and mortality. Quality of life hampers due to its chronic nature and painful crisis.…

ABSTRACTObjectiveTo investigate immunophenotypic alterations in regulatory T cells (Tregs) and neutrophil dynamics in adult sickle cell anemia (SCA) patients during…

The Uganda Sickle Surveillance Study (US3) documented sickle cell anemia (SCA) throughout the country. An important corollary was identification of infants born…