Clinical Trials and Research

AbstractBackground: People with sickle cell disease (SCD) are at risk for accelerated biological aging and functional decline due to both age and SCD-related…

Key PointsQuestion  Do hydroxyurea use (ie, taking the medication at all) and adherence (ie, days taken per week) change over time, and are they associated…

ObjectivesTo determine whether adults with sickle cell disease (SCD) without glaucoma exhibit subclinical structural optic neuropathy (SON) on optical coherence…

What are the main findings?Endothelial dysfunction is a hallmark of sickle cell disease (SCD), which is associated with both acute and chronic crises in patients.…

Sickle cell disease is the scourge of a person’s red blood cells. The inherited blood disorder, which disproportionately affects people in sub-Saharan Africa and…

Key PointsThis is the first SCD project to implement a privacy-preserving technique for linking individuals across multiple registries.Linkage of multiple…

Article summarySickle Cell Disease (SCD) poses a significant health challenge in low- and middle-income countries, particularly in sub-Saharan Africa, where access…

AbstractKey points: Renin-angiotensin system inhibitor use was not associated with slowed GFR decline in sickle cell disease. This null association did not change…

The Consortium on Newborn Screening in Africa (CONSA), launched by the American Society of Hematology in 2020, is designed to initiate and expand sustainable…

AbstractImportance: Sickle cell disease (SCD) disproportionately affects racial and ethnic minority groups in the US and is associated with high levels of morbidity…