Clinical Trials and Research

AbstractBordetella hinzii is a rare, opportunistic Gram-negative bacterium traditionally associated with poultry but increasingly identified as a human pathogen in…

HighlightsSickle cell trait can cause severe, transfusion-dependent hematuria -- not always benign; requires thorough evaluation.Consider renal papillary necrosis…

AbstractSickle cell disease (SCD) is a type of inherited disorder of hemoglobin characterized by recurring vaso-occlusive pain crises that affect many organ systems…

AbstractPregnancy in Sickle Cell Disease (SCD), a severe hereditary genetic condition, highly prevalent in Sub-Saharan African countries, is associated with…

Orbital compression syndrome (OCS), also referred to in the sickle cell disease (SCD) literature as orbital infarction syndrome, is an uncommon but potentially…

AbstractSickle cell disease (SCD) is a monogenic hemoglobinopathy in which hemoglobin S (HbS) polymerizes on deoxygenation, leading to sickling of red blood cells (…

AbstractBackground: Sickle cell disease (SCD) is a major cause of morbidity and mortality among children in sub-Saharan African. Hydroxyurea (HU) remains the…

Background: Sickle Cell Disease (SCD) causes acute and chronic complications. Hydroxyurea (HU) reduces vaso-occlusive crises (VOCs), and improves patients’ outcomes…

Zydus Lifesciences is advancing its clinical pipeline with permission to start Phase III clinical trials of Desidustat, an oral therapeutic candidate for Sickle…

AbstractSickle cell disease (SCD) is a globally distributed hereditary red cell disorder with still high mortality. Growing evidence indicates that sickle cell…