Clinical Trials and Research

TOPLINEPeople with sickle cell disease (SCD) had 82% higher odds of receiving immediate postpartum long-acting reversible contraception (LARC) than those without…

In the manuscript  “Sickle Cell Disease: From Ancient Origins to Modern Break-2 throughs in Gene Therapy” by Drs. Bawo Ikolo et al, the authors  examine…

AbstractAllogeneic hematopoietic stem cell transplantation (HSCT) is the only widely available cure for sickle cell disease (SCD), yet its use in adults has…

AbstractIntroduction Sickle cell disease is a monogenic blood disorder prevalent in Africa, where malaria poses a health risk for affected individuals. Individuals…

Scientists at St. Jude Children’s Research Hospital found that prematurely old blood stem cells from sickle cell disease may be treatable with anti-aging drugs, and…

Suggestions target more effective communication to boost patient participationIn the U.S., doctors who care for people with sickle cell disease (SCD) often don’t…

Sickle cell disease (SCD) is a chronic, inherited condition rising across the globe. Prior studies revealed a direct link between the gut microbiome and disease…

AbstractSickle cell disease (SCD) is a monogenic disorder marked by hemoglobin S polymerization, resulting in chronic hemolysis, vaso-occlusion, systemic…

The multicenter trial is evaluating a CRISPR-Cas9 approach designed to directly modify the beta‑globin gene in sickle cell disease.FDA-approved gene therapies have…

AbstractBackground: Sickle cell disease (SCD) is the most common inherited blood disorder globally, affecting approximately 300,000 newborns annually. Cardiac…