Clinical Trials and Research

AbstractBackground: Sickle cell anemia is an autosomal recessive disorder caused by abnormal hemoglobin S, which polymerizes when deoxygenated and distorts…

AbstractAdults living with sickle cell disease (SCD) experience high rates of chronic pain, depression, and anxiety, which significantly impair quality of life.…

In 2010, analysis of the Dallas Newborn Cohort established a new reality for sickle cell disease (SCD): more than 90% of affected infants born after 1983 survive to…

AbstractChildren with sickle cell anemia (SCA) are at increased risk of cerebrovascular complications due to chronic anemia and progressive vascular injury, yet how…

AbstractVaso-occlusive crisis is the primary cause of morbidity and emergency department visits in patients with sickle cell disease (SCD) and may lead to acute…

Risk factors and outcomes of high-impact chronic pain (HICP), ie, chronic pain (CP) and substantial restriction of participation in work, social, or self-care…

AbstractSickle cell disease (SCD) and thalassemia are genetic disorders that necessitate accurate diagnosis for effective management and improved patient outcomes.…

The spleen is one of the first organs injured in sickle cell disease (SCD) [1]. Splenic impairment in SCD children can silently progress toward functional asplenia…

AbstractBackground and objectivesSickle cell disease is a major haemoglobin disorder, and foetal haemoglobin (HbF) remains the strongest modifier of disease…

AbstractImportance: Suboptimal transitions from pediatric to adult health care can negatively impact disease outcomes, medication regimen adherence, and disease…