Clinical Trials and Research

Article summarySickle Cell Disease (SCD) poses a significant health challenge in low- and middle-income countries, particularly in sub-Saharan Africa, where access…

The Consortium on Newborn Screening in Africa (CONSA), launched by the American Society of Hematology in 2020, is designed to initiate and expand sustainable…

AbstractImportance: Sickle cell disease (SCD) disproportionately affects racial and ethnic minority groups in the US and is associated with high levels of morbidity…

Sickle cell disease (SCD) is one of the most common inherited blood disorders worldwide, impacting millions of people globally and most…

The wide interindividual variability in clinical response to hydroxyurea therapy in the management of sickle cell disease has limited its use. These variabilities…

AbstractBackgroundAsthma is a frequent comorbidity in children with sickle cell disease and has been associated with an increased risk of acute complications,…

AbstractThalassemia and sickle cell disease are inherited hemoglobinopathies caused by pathogenic variants in the globin genes and represent a major global health…

Introduction: Sickle Cell Disease (SCD) is a common inherited haemoglobinopathy with significant oral and systemic implications. Despite its prevalence in multi-…

Hematopoietic stem cell transplantation (HSCT) is both possible and effective in adult patients with sickle cell disease (SCD), according to a…

A global, late-stage clinical trial testing etavopivat in people with sickle cell disease (SCD) has hit its main goals, showing that the experimental oral therapy…