Clinical Trials and Research

In season 1, episode 2 of the popular show The Pitt, a Black woman with sickle cell disease arrives at the emergency department in acute pain, only to be…

Treatment with ristoglogene autogetemcel (risto-cel) cell therapy led to rapid engraftment, improved fetal hemoglobin (HbF) expression, and reduced vaso-occlusive…

Sickle cell disease (SCD) is characterised by the polymerisation of haemoglobin S (HbS) under low oxygen conditions, causing red blood cells to become rigid and…

AbstractPatients with sickle cell disease (SCD) experience multisystem complications, with sickle cell nephropathy being a major contributor to chronic kidney…

The RUBY trial demonstrates that disrupting the BCL11A binding site in the γ-globin promoters can normalize hemoglobin in severe sickle cell disease.Background: The…

The BEACON clinical trial showed therapy's lasting benefits in 31 patientsBeam Therapeutics plans to ask the U.S. Food and Drug Administration (FDA) to approve…

Background: Sickle cell disease is a hereditary hemoglobinopathy commonly seen in sub-Saharan Africa, India, and the Middle East. It is caused by a mutation in the…

Ngoe Samuel BakiaDepartment of Pharmaceutical Sciences, Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Cameroon.Chetcha Bernard…

Gene therapy eliminated pain and improved blood counts in most patients with sickle cell disease in a major trial.New results from a clinical trial show promising…

AbstractSickle Cell Disease (SCD) remains a public health challenge in India, particularly among tribal populations. Gaps persist in early detection, awareness, and…