Clinical Trials and Research

Sickle cell disease (SCD) is a hereditary hemoglobinopathy characterized by chronic hemolytic anemia, recurrent vaso-occlusive crises, progressive organ damage, and…

CAMBRIDGE, Mass., May 12, 2026 (GLOBE NEWSWIRE) -- Agios Pharmaceuticals, Inc. (Nasdaq: AGIO), a commercial-stage biopharmaceutical company focused on delivering…

Sickle cell disease (SCD) is one of the most prevalent autosomal recessive conditions worldwide, affecting more than 600,000 newborns annually. Despite advances in…

HLA-matched sibling donor (MSD) hematopoietic cell transplantation (HCT) done prior to adolescence demonstrated promising safety and efficacy outcomes among…

AbstractBackground: People with sickle cell disease (SCD) are at risk for accelerated biological aging and functional decline due to both age and SCD-related…

Key PointsQuestion  Do hydroxyurea use (ie, taking the medication at all) and adherence (ie, days taken per week) change over time, and are they associated…

ObjectivesTo determine whether adults with sickle cell disease (SCD) without glaucoma exhibit subclinical structural optic neuropathy (SON) on optical coherence…

What are the main findings?Endothelial dysfunction is a hallmark of sickle cell disease (SCD), which is associated with both acute and chronic crises in patients.…

Sickle cell disease is the scourge of a person’s red blood cells. The inherited blood disorder, which disproportionately affects people in sub-Saharan Africa and…

Key PointsThis is the first SCD project to implement a privacy-preserving technique for linking individuals across multiple registries.Linkage of multiple…