Clinical Trials and Research

Sickle cell disease (SCD) is a monogenic disorder where autologous gene therapy may offer a safer curative alternative to allogeneic transplantation. We report…

Sickle cell disease (SCD) is a complex condition that results in low oxygen affinity and oxidative damage within red blood cells (RBCs), which contributes to…

AbstractBackgroundVitamin A is involved in the proliferation and maintenance of the epithelial cells of the respiratory tract. Since maintenance of the integrity of…

APhase III trial of Novo Nordisk’s once-daily tablet has met both co-primary endpoints, reducing vaso-occlusive crises (VOC) and increasing haemoglobin (Hb)…

Sickle cell disease (SCD) is characterized by abnormal polymerization of deoxygenated hemoglobin S. This polymerization leads to the distinctive sickling of red…

Sickle cell patients are more likely than other patients to have negative descriptions in their medical charts, such as “noncompliant” and “noncooperative,”…

AbstractBackgroundSickle cell disease (SCD) is one of the most common monogenic disorders in the world. Patients with SCD have chronic hemolytic anemia and…

Department of Development Studies, School of Public Health and Social Sciences, Muhimbili University of Health and Allied Sciences, Dar es Salaam P.O. Box 65001,…

ABSTRACTObjectiveTo investigate immunophenotypic alterations in regulatory T cells (Tregs) and neutrophil dynamics in adult sickle cell anemia (SCA) patients during…

The Uganda Sickle Surveillance Study (US3) documented sickle cell anemia (SCA) throughout the country. An important corollary was identification of infants born…